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KMID : 0371320110810060394
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Journal of the Korean Surgical Society
2011 Volume.81 No. 6 p.394 ~ p.401
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Factors affecting long-term survival after surgical resection of pancreatic ductal adenocarcinoma
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Yoon Kyoung-Won
Heo Jin-Seok
Choi Dong-Wook
Choi Seoung-Ho
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Abstract
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Purpose: Some patients who undergo surgical resection of pancreatic cancer survive longer than other patients. The purpose of this study was to identify the factors that affect long-term survival after resection of histopathologically confirmed pancreatic ductal adenocarcinoma.
Methods: A single-center, retrospective study was conducted among 164 patients who underwent surgical resection of pancreatic cancer, between May 1995 and December 2004. The patient follow-up process was conducted via telephone survey and review of electronic medical records for at least 5 years or until death.
Results: We compared patients with long-term (≥60 months, n = 19) and short-term survival (<60 months, n = 145). Resection margin status, differentiation of the tumor, tumor stage, pre-operative serum level of albumin, total bilirubin and carbohydrate antigen (CA) 19-9 level are related with survival difference (all factors, P < 0.05). Multivariate analysis revealed that a pre-operative serum total bilirubin level <7 mg/dL and a pre-operative serum CA19-9 level <37 U/mL is a statistically significant prognostic factor for long-term survival.
Conclusion: The preoperative serum total bilirubin and serum CA19-9 levels are associated with long-term survival after surgical resection of pancreatic cancer.
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KEYWORD
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Pancreatic neoplasms, Bilirubin, CA19-9 antigen
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